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. Author manuscript; available in PMC: 2006 Mar 1.
Published in final edited form as: Blood. 2004 Sep 16;105(5):2016–2022. doi: 10.1182/blood-2004-05-1915

Figure 1.

Figure 1

Immunization of mice with DCs loaded with bcr-abl+ leukemia-derived CRCL induces BCR-ABL–specific IFN-γ secretion. Mice were immunized with DCs (5 × 105) loaded with 12B1- or 32Dp210-derived CRCL, or with a BCR-ABL peptide, GFKQSSKAL, or with an irrelevant peptide, HYLSTQSALSK, on days −14 and −7. Control mice were immunized with equal volumes of PBS or equal numbers of empty DCs. On day 0, splenocytes were collected and restimulated with indicated peptide or CRCL for 48 hours. IFN-γ production was determined by ELISPOT assay. Error bars represent SEM.