Figure 2.

NMR structure of the Hif-1α:TAZ1 complex. (A) Stereo view of the best 20 structures superposed on backbone heavy atoms in ordered regions. The TAZ1 backbone is shown in blue, Hif-1α in pink, and the N and C termini of each chain are labeled in the corresponding colors. Bound zinc ions are shown as yellow spheres. (B) Ribbon representation of a single structure in a similar orientation to A. Helices α₁–α₄ of TAZ1 and α_A–α_C of the Hif-1α CAD are labeled. The zinc ions are represented as white spheres, and the side chains of the cysteine and histidine ligands are shown in yellow and blue, respectively.