Table 5. Synthesis of pyrimido[4,5-b]quinoline derivatives in the presence of the catalyst.
| Entry | Product | Time (min) | Yielda (%) | M.p. °C (Lit.) |
|---|---|---|---|---|
| 1 |
|
15 | 89 | 244–245 (253–255)17 |
| 2 |
|
10 | 81 | 346–350 (—) |
| 3 |
|
12 | 89 | 247–249 (238–240)37 |
| 4 |
|
10 | 95 | 347–351 (350–355)17 |
| 5 |
|
19 | 85 | 293–296 (>300)24 |
| 6 |
|
24 | 79 | 346–349 (—) |
| 7 |
|
25 | 78 | 289–293 (285–287)24 |
| 8 |
|
30 | 85 | 296–298 (>300) |
| 9 |
|
10 | 85 | 288–289 (292–294)24 |
| 10 |
|
40 | 83 | 298–301 (300–303)17 |
| 11 |
|
10 | 97 | 225–229 (226–229)35 |
| 12 |
|
35 | 95 | 315–320 (>300)24 |
| 13 |
|
20 | 93 | 278–282 (301–303)35 |
| 14 |
|
25 | 99 | 310–314 (>300)32 |
| 15 |
|
10 | 98 | 280–284 (208–212)19 |
Isolated yield.