Table 3.
Diagnostic performance of the clinical variables for clinically significant prostate cancer
| Clinical variable | AUC | 95% CI | Sensitivity (%) | Specificity (%) | P |
|---|---|---|---|---|---|
| PI-RADS 1–2 | |||||
| Age | 0.509 | 0.455–0.563 | 88.24 | 25.08 | Reference |
| BMI | 0.561 | 0.507–0.614 | 41.18 | 83.69 | 0.624 |
| tPSA | 0.612 | 0.559–0.663 | 76.47 | 54.08 | 0.166 |
| PV | 0.789 | 0.742–0.830 | 88.24 | 61.03 | 0.005 |
| PSAD | 0.843 | 0.801–0.880 | 88.24 | 80.06 | <0.001 |
| PI-RADS 3 | |||||
| Age | 0.577 | 0.499–0.652 | 33.33 | 83.80 | Reference |
| BMI | 0.513 | 0.435–0.591 | 77.78 | 11.27 | 0.437 |
| tPSA | 0.591 | 0.513–0.666 | 44.44 | 78.87 | 0.847 |
| PV | 0.808 | 0.740–0.864 | 85.19 | 68.31 | 0.004 |
| PSAD | 0.775 | 0.704–0.835 | 85.19 | 59.15 | 0.009 |
| All patients | |||||
| Age | 0.553 | 0.509–0.597 | 97.73 | 12.05 | Reference |
| BMI | 0.531 | 0.487–0.575 | 27.27 | 87.74 | 0.761 |
| tPSA | 0.611 | 0.567–0.653 | 72.73 | 48.63 | 0.270 |
| PV | 0.794 | 0.756–0.828 | 84.09 | 65.12 | <0.001 |
| PSAD | 0.806 | 0.769–0.839 | 77.27 | 73.36 | <0.001 |
PI-RADS: Prostate Imaging Reporting and Data System; BMI: body mass index; tPSA: total prostate-specific antigen; PV: prostate volume; PSAD: prostate-specific antigen density; AUC: area under curve; 95% CI: 95% confidence interval