Skip to main content
. 2002 Mar 26;99(8):5486–5491. doi: 10.1073/pnas.072626199

Figure 3.

Figure 3

The present-day and ancestral sequences of EDN and ECP. Only the mature peptides (without signal sequences) are shown. The two important sites discussed in the text are boxed. The three major catalytic residues and eight structural cysteines are marked with solid and open arrows, respectively. The ancestral amino acids with <50% posterior probabilities are underlined. The parsimony alternative ancestral states are P, or G, or L at site 21; R, or T, or A at site 65; and S or D at site 99. Experiments show that these three sites are unimportant to the RNase activity. “?” in ancestor B indicates equally parsimonious inferences of Arg or Val. CE macaque, crab-eating macaque; PT macaque, pig-tailed macaque; SQ monkey, squirrel monkey; CT tamarin, cotton-top tamarin; RB tamarin, red-bellied tamarin.