Table 2.
Cox regression model calculating the association between MACE events during follow-up and Lp(a) categories: the highest Lp(a) category (≥90 mg/dl) vs. the lowest category (<30 mg/dl), stratified for length of follow-up (increasing from 0 to 12 months, plus 6 months each).
| Follow-up (months) | Model 1 | Model 2 | ||||||
|---|---|---|---|---|---|---|---|---|
| n events; incidencea | HR (95% CI) | p-value | n events; incidencea | HR (95% CI) | p-value | |||
| <30 mg/dl (N = 951) | ≥90 mg/dl (N = 51) | <30 mg/dl (N = 939) | ≥90 mg/dl (N = 48) | |||||
| Overall | 223; 34.6 | 14; 43.6 | 1.21 (0.70–2.08) | 0.49 | 221; 34.9 | 13; 42.2 | 1.22 (0.69–2.16) | 0.48 |
| 0–12 | 30; 31.9 | 5; 103.5 | 3.02 (1.17–7.81) | 0.022 | 29; 31.5 | 4; 87.6 | 3.10 (1.05–9.16) | 0.040 |
| 0–18 | 45; 32.2 | 7; 99.1 | 2.90 (1.31–6.45) | 0.009 | 44; 32.2 | 6; 89.6 | 3.43 (1.43–8.27) | 0.006 |
| 0–24 | 66; 35.9 | 9; 97.9 | 2.57 (1.28–5.16) | 0.008 | 65; 36.1 | 8; 91.6 | 3.11 (1.46–6.63) | 0.003 |
| 0–30 | 79; 34.8 | 10; 89.0 | 2.42 (1.25–4.68) | 0.009 | 78; 35.0 | 9; 84.4 | 2.96 (1.46–6.02) | 0.003 |
| 0–36 | 90; 33.4 | 10; 75.6 | 2.14 (1.11–4.12) | 0.022 | 89; 33.7 | 9; 71.6 | 2.49 (1.23–5.02) | 0.011 |
| 0–42 | 110; 35.5 | 11; 72.3 | 1.94 (1.04–3.61) | 0.036 | 109; 35.9 | 10; 69.2 | 2.08 (1.08–4.03) | 0.030 |
| 0–48 | 120; 34.4 | 11; 64.3 | 1.77 (0.96–3.29) | 0.069 | 119; 34.8 | 10; 61.6 | 1.92 (1.00–3.71) | 0.051 |
| 0–54 | 134; 34.6 | 11; 57.9 | 1.59 (0.86–2.94) | 0.14 | 133; 35.0 | 10; 55.4 | 1.67 (0.87–3.21) | 0.12 |
| 0–60 | 145; 34.1 | 11; 52.6 | 1.46 (0.79–2.70) | 0.22 | 143; 34.3 | 10; 50.4 | 1.52 (0.79–2.92) | 0.21 |
Model 1: age and sex; Model 2: age, sex, body mass index, Mediterranean diet score, food intake, glucose, total cholesterol, statin treatment; in bold p < 0.05.
a
Per 1,000 person-years.