Table 2.
Clinical outcomes
| Outcome | AD dementia severity | p Value1 | Overall population | ||
|---|---|---|---|---|---|
| Mild | Moderate | Moderately severe/severe | |||
| No. of patients | 29 | 80 | 89 | 198 | |
| MMSE | 23.0 (22.3; 23.6) | 17.8 (17.4; 18.1) | 10.4 (9.7; 11.1) | 2 | 15.2 (14.5; 16.0) |
| ADCS-ADL – basic | 17.9 (16.2; 19.6) | 16.7 (15.6; 17.8) | 12.0 (10.8; 13.2) | <0.001 | 14.8 (13.9; 15.6) |
| ADCS-ADL – instrumental | 32.9 (29.0; 36.8) | 25.5 (22.4; 28.5) | 13.5 (11.1; 16.0) | <0.001 | 21.2 (19.2; 23.2) |
| ADCS-ADL – total | 50.8 (45.5; 56.1) | 42.2 (38.3; 46.2) | 25.5 (22.1; 29.0) | <0.001 | 36.0 (33.3; 38.8) |
| ADAS-Cog14 | 35.2 (32.5; 37.9) | 47.0 (45.0; 49.0) | Not applied | <0.001 | 43.8 (41.9; 45.7) |
| NPI-12 total | 15.5 (11.4; 19.6) | 20.0 (16.5; 23.5) | 25.5 (21.5; 29.5) | 0.011 | 21.8 (19.4; 24.2) |
| EQ-5D country-specific index score (proxy) | 0.81 (0.76; 0.85) | 0.79 (0.76; 0.82) | 0.76 (0.72; 0.80) | 0.248 | 0.78 (0.75; 0.80) |
| EQ-VAS (proxy) | 61.2 (54.7; 67.7) | 63.7 (59.0; 68.3) | 59.8 (54.5; 65.2) | 0.544 | 61.6 (58.4; 64.8) |
AD=Alzheimer's disease; ADAS-Cog14=14-item cognitive subscale of the Alzheimer's disease assessment scale; ADCS-ADL=Alzheimer's Disease Co-operative Study Activities of Daily Living Inventory; ANOVA=analysis of variance; EQ-5D=EuroQoL-5D; EQ-VAS=EQ-5D visual analogue scale; MMSE=Mini-Mental State examination; NPI=neuropsychiatric inventory. Data are presented as means (95% confidence interval) for the total population of each severity group with available data (0–3% missing). 1p Value for comparison between AD dementia severity groups (ANOVA). 2No statistical analysis performed. ‘Mild’ AD dementia severity = MMSE score of 21–26 points; ‘Moderate’ AD dementia severity = MMSE score of 15–20 points; ‘Moderately severe/severe’ AD dementia severity = MMSE score of <15 points. Reduced functioning is indicated by lower scores for MMSE and ADCS-ADL; greater cognitive impairment is indicated by higher scores for ADAS-Cog14; increased impairment is indicated by higher scores for NPI-12 total score; reduced quality of life is indicated by lower scores for EQ-5D.