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. 2002 Apr 16;99(8):5616–5621. doi: 10.1073/pnas.082613599

Figure 4.

Figure 4

Expression of the CT transgene in mdx muscles inhibits elevations in serum creatine kinase activity. Serum creatine kinase activity was measured in Wt, CT, mdx, and mdx/CT animals at various ages. Serum creatine kinase activity was increased in mdx mice by an order of magnitude compared with Wt mice (P < 0.001 for all). Serum creatine kinase activity was reduced in mdx/CT mice (P < 0.001, compared with mdx, for all) and was not significantly different from wild-type levels (P > 0.05). For Wt, n = 40 (5 weeks) and 15 (6 months); CT, n = 32 (5 weeks) and 12 (6 months); mdx, n = 14 (5 weeks), 10 (3 months), and 14 (6 months); mdx/CT, n = 10 (5 weeks), 8 (3 months), and 14 (6 months).