Figure 7.

Immunostaining of dystrophin-associated proteins in mdx and mdx/CT mice. In mdx mice, very little if any expression of utrophin, α- and β-dystroglycan, α- and β-sarcoglycan, or dystrobrevin was evident in myofibers, In mdx/CT mice, by contrast, all of these proteins were highly expressed around and sometimes within myofibers. Laminin α2 was expressed in the basal lamina surrounding muscles from both mice. Desmin and NCAM were highly expressed in regenerating fibers in mdx muscles and were also highly expressed in mdx/CT muscles. (Bar = 25 μm.)