Table 2.
Significant associations of metabolites/indicators with the respective hepatic phenotype adjusted for the full model
| Metabolite or Indicator | Estimate (95% CI) | FDR corrected p-value | Log10 p-value |
|---|---|---|---|
| Fat | |||
| Ala | 1.17 (1.08, 1.26) | 0.009 | 2.06 |
| Ile | 1.13 (1.05, 1.22) | 0.031 | 1.51 |
| Leu | 1.13 (1.05, 1.22) | 0.031 | 1.51 |
| alpha.AAA | 1.14 (1.05, 1.23) | 0.031 | 1.51 |
| lysoPC a C17.0 | 0.88 (0.81, 0.95) | 0.04 | 1.39 |
| PC ae C38.2 | 0.88 (0.82, 0.95) | 0.031 | 1.51 |
| bcaa | 1.13 (1.05, 1.21) | 0.024 | 1.62 |
| keto_aa | 1.13 (1.05, 1.21) | 0.024 | 1.62 |
| PCae_PCaa | 0.86 (0.79, 0.94) | 0.024 | 1.62 |
| Fat male | |||
| C14 | 1.19 (1.08, 1.31) | 0.037 | 1.44 |
| C16 | 1.18 (1.07, 1.3) | 0.037 | 1.44 |
| Ala | 1.19 (1.07, 1.31) | 0.037 | 1.44 |
| alpha.AAA | 1.18 (1.07, 1.31) | 0.037 | 1.44 |
| PC aa C32.1 | 1.21 (1.08, 1.35) | 0.037 | 1.44 |
| keto_aa | 1.18 (1.07, 1.3) | 0.027 | 1.57 |
| Hepatic steatosis | |||
| Glu | 1.72 (1.24, 2.41) | 0.049 | 1.31 |
| lysoPC a C17.0 | 0.55 (0.39, 0.76) | 0.035 | 1.46 |
| PC ae C34.3 | 0.56 (0.4, 0.76) | 0.035 | 1.46 |
| PC ae C36.2 | 0.59 (0.42, 0.81) | 0.049 | 1.31 |
| PC ae C38.2 | 0.62 (0.45, 0.83) | 0.049 | 1.31 |
| Iron | |||
| C0 | 1.02 (1.01, 1.03) | 0.031 | 1.52 |
| C7.DC | 1.02 (1.01, 1.03) | 0.031 | 1.51 |
| Alpha.AAA | 1.02 (1.01, 1.03) | 0.046 | 1.34 |
| Lysopc a C20.4 | 1.02 (1.01, 1.03) | 0.031 | 1.51 |
| PC aa C36.4 | 1.02 (1.01, 1.04) | 0.028 | 1.55 |
| PC aa C38.4 | 1.03 (1.01, 1.04) | 0.005 | 2.29 |
| PC aa C38.5 | 1.02 (1.01, 1.04) | 0.018 | 1.75 |
| PC aa C40.5 | 1.02 (1.01, 1.04) | 0.028 | 1.55 |
| PC ae C36.4 | 1.02 (1.01, 1.03) | 0.031 | 1.51 |
| PC ae C36.5 | 1.02 (1.01, 1.03) | 0.031 | 1.51 |
| PC ae C38.5 | 1.02 (1.01, 1.03) | 0.046 | 1.34 |
| PC ae C38.6 | 1.02 (1.01, 1.03) | 0.046 | 1.34 |
| SM C18.1 | 1.02 (1.01, 1.03) | 0.04 | 1.4 |
| SM C20.2 | 1.02 (1.01, 1.03) | 0.031 | 1.51 |
| Iron male | |||
| PC aa C34.4 | 1.04 (1.02, 1.05) | 0.038 | 1.42 |
| SM C20.2 | 1.03 (1.01, 1.05) | 0.038 | 1.42 |
| Iron overload | |||
| C2 | 1.53 (1.18, 1.98) | 0.045 | 1.35 |
| C7.DC | 1.46 (1.14, 1.88) | 0.045 | 1.35 |
| C14.1 | 1.49 (1.16, 1.93) | 0.045 | 1.35 |
| Alpha.AAA | 1.5 (1.15, 1.96) | 0.045 | 1.35 |
| PC aa C36.4 | 1.53 (1.18, 2.01) | 0.045 | 1.35 |
| PC aa C38.4 | 1.5 (1.15, 1.97) | 0.045 | 1.35 |
| PC aa C38.5 | 1.52 (1.17, 1.99) | 0.045 | 1.35 |
| PC aa C38.6 | 1.57 (1.21, 2.05) | 0.045 | 1.35 |
| PC aa C40.6 | 1.51 (1.17, 1.97) | 0.045 | 1.35 |
| PC ae C36.5 | 1.46 (1.14, 1.89) | 0.045 | 1.35 |
| PC ae C38.6 | 1.45 (1.14, 1.87) | 0.045 | 1.35 |
| Bcaa | 1.45 (1.12, 1.88) | 0.033 | 1.49 |
| Total_AC | 1.52 (1.18, 1.97) | 0.02 | 1.71 |
| Total_longAC | 1.44 (1.12, 1.86) | 0.033 | 1.49 |
| Total_shortAC | 1.56 (1.21, 2.02) | 0.02 | 1.71 |
| Total_mufaAC | 1.43 (1.11, 1.86) | 0.033 | 1.49 |
| Total_sfaAC | 1.52 (1.18, 1.98) | 0.02 | 1.71 |
| Total_pufaPCax | 1.5 (1.16, 1.96) | 0.025 | 1.61 |
| Total_PCax | 1.44 (1.1, 1.88) | 0.039 | 1.41 |
| Total_PCaa | 1.43 (1.09, 1.88) | 0.045 | 1.34 |
| GGT | |||
| Asp | 1.14 (1.07, 1.21) | 0.001 | 2.89 |
| Glu | 1.19 (1.11, 1.27) | 0 | 4.04 |
| Phe | 1.15 (1.08, 1.22) | 0.001 | 2.96 |
| PC aa C38.3 | 1.13 (1.06, 1.22) | 0.01 | 2 |
| PC aa C38.4 | 1.13 (1.06, 1.21) | 0.007 | 2.19 |
| PC aa C40.4 | 1.11 (1.04, 1.19) | 0.019 | 1.71 |
| PC aa C40.5 | 1.12 (1.05, 1.19) | 0.015 | 1.83 |
| PC aa C40.6 | 1.11 (1.04, 1.18) | 0.025 | 1.6 |
| PC ae C40.2 | 1.11 (1.04, 1.18) | 0.015 | 1.83 |
| SM C18.0 | 1.16 (1.09, 1.23) | 0 | 3.57 |
| SM C18.1 | 1.12 (1.05, 1.19) | 0.013 | 1.9 |
| SM C20.2 | 1.11 (1.05, 1.18) | 0.013 | 1.89 |
| SM C24.1 | 1.14 (1.07, 1.21) | 0.001 | 2.96 |
| Cit_arg | 0.91 (0.85, 0.97) | 0.035 | 1.46 |
| Pla2 | 0.9 (0.84, 0.97) | 0.035 | 1.46 |
| Total_SM | 1.1 (1.03, 1.17) | 0.035 | 1.46 |
| total_SM_nonOH | 1.1 (1.03, 1.17) | 0.035 | 1.46 |
| GGT male | |||
| Asp | 1.14 (1.06, 1.23) | 0.02 | 1.71 |
| Glu | 1.19 (1.09, 1.29) | 0.004 | 2.36 |
| PC aa C32.1 | 1.15 (1.05, 1.27) | 0.043 | 1.37 |
| PC aa C36.4 | 1.16 (1.07, 1.27) | 0.015 | 1.82 |
| PC aa C38.3 | 1.15 (1.05, 1.26) | 0.042 | 1.38 |
| PC aa C38.4 | 1.19 (1.1, 1.29) | 0.004 | 2.43 |
| PC aa C40.4 | 1.2 (1.1, 1.3) | 0.004 | 2.43 |
| PC aa C40.5 | 1.14 (1.05, 1.24) | 0.037 | 1.43 |
| SM C18.0 | 1.13 (1.05, 1.22) | 0.036 | 1.45 |
| Total_pufaPCax | 1.14 (1.05, 1.23) | 0.033 | 1.48 |
| Total_PCax | 1.15 (1.05, 1.25) | 0.033 | 1.48 |
| Total_PCaa | 1.15 (1.05, 1.25) | 0.033 | 1.48 |
| GGT female | |||
| Phe | 1.23 (1.1, 1.36) | 0.026 | 1.58 |
| SM_PC | 1.23 (1.09, 1.37) | 0.02 | 1.69 |
| ALT | |||
| PC aa C40.6 | 1.09 (1.04, 1.14) | 0.012 | 1.91 |
| PC aa C42.5 | 1.09 (1.04, 1.14) | 0.012 | 1.91 |
| pufaPC_sfaPC | 0.92 (0.88, 0.97) | 0.032 | 1.49 |
| AST | |||
| pufaPC_sfaPC | 0.93 (0.89, 0.96) | 0.005 | 2.32 |
Abbreviations CI Confidence interval