Figure 4.

(A) Length of the OS (in μm) of retinas of Rp1 mutant mice at different ages. Each point represents average measurements from one animal. (Inset) Illustrates measurements at ages from P7 to P25. (B) TEM of the ultrastructure (×6,000) of OS in the Rp1^+/+ (1M+/+) and Rp1^−/− (1M−/−) retinas at 1 month. Cross section (×50,000) of connecting cilia of Rp1^−/− retina appears normal (Inset). Disoriented discs (arrowhead), whorls, and disk membranes (arrows) of abnormal sizes were found in Rp1^−/− retina, and the OS layer became shortened with age.