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. Author manuscript; available in PMC: 2025 Jul 23.
Published in final edited form as: Physiol Rev. 2025 Jan 15;105(3):1291–1428. doi: 10.1152/physrev.00034.2023

Figure 12. Location of NOX single nucleotide variations (SNVs) and single nucleotide polymorphisms (SNPs).

Figure 12.

Diagrammatic representation of the specific locations of SNVs (red dots) and SNPs (black dots) in NOX catalytic subunits discussed in the text. EFh, EF-hand domain (calcium-binding domain); FAD, flavin adenine dinucleotide domain; FRD, ferric reductase domain; NADPH, nicotinamide-adenine dinucleotide phosphate domain; Peroxidase, peroxidase domain; TM, transmembrane domain. Note: For visualization purposes, only NOXs that contain pertinent coding non-synonymous mutations discussed in the manuscript are shown.