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Published in final edited form as: Physiol Rev. 2025 Jan 15;105(3):1291–1428. doi: 10.1152/physrev.00034.2023

Figure 9. — Differential expression between tumor and adjacent normal tissues for NOX enzymes across tumor types in The Cancer Genome Atlas (TCGA). Distributions of gene expression levels are displayed using box plots. Genes that are upregulated or downregulated in the tumors are compared to normal tissues for each cancer type. mRNA expression of the indicated NOX isoform in normal (blue) and tumor (red) samples, each dot represents a different patient obtained from the TCGA database (https://portal.gdc.cancer.gov). BLCA=Bladder Urothelial Carcinoma, BRCA=Breast invasive carcinoma, CESC=Cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL=Cholangiocarcinoma, COAD=Colon adenocarcinoma, ESCA=Esophageal carcinoma, GBM=Glioblastoma multiforme, HNSC=Head and Neck squamous cell carcinoma, KICH=Kidney Chromophobe, KIRC=Kidney renal clear cell carcinoma, KIRP=Kidney renal papillary cell carcinoma, LIHC=Liver hepatocellular carcinoma, LUAD=Lung adenocarcinoma, LUSC=Lung squamous cell carcinoma, PAAD=Pancreatic adenocarcinoma, PCPG=Pheochromocytoma and Paraganglioma, PRAD=Prostate adenocarcinoma, READ=Rectum adenocarcinoma, SKCM=Skin Cutaneous Melanoma, STAD=Stomach adenocarcinoma, THCA=Thyroid carcinoma, UCEC=Uterine Corpus Endometrial Carcinoma. Wilcoxon test showing significance between tumor and adjacent tissue at * p<0.05, **p<0.01, ***p<0.001.

Figure 9. — Differential expression between tumor and adjacent normal tissues for NOX enzymes across tumor types in The Cancer Genome Atlas (TCGA). Distributions of gene expression levels are displayed using box plots. Genes that are upregulated or downregulated in the tumors are compared to normal tissues for each cancer type. mRNA expression of the indicated NOX isoform in normal (blue) and tumor (red) samples, each dot represents a different patient obtained from the TCGA database (https://portal.gdc.cancer.gov). BLCA=Bladder Urothelial Carcinoma, BRCA=Breast invasive carcinoma, CESC=Cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL=Cholangiocarcinoma, COAD=Colon adenocarcinoma, ESCA=Esophageal carcinoma, GBM=Glioblastoma multiforme, HNSC=Head and Neck squamous cell carcinoma, KICH=Kidney Chromophobe, KIRC=Kidney renal clear cell carcinoma, KIRP=Kidney renal papillary cell carcinoma, LIHC=Liver hepatocellular carcinoma, LUAD=Lung adenocarcinoma, LUSC=Lung squamous cell carcinoma, PAAD=Pancreatic adenocarcinoma, PCPG=Pheochromocytoma and Paraganglioma, PRAD=Prostate adenocarcinoma, READ=Rectum adenocarcinoma, SKCM=Skin Cutaneous Melanoma, STAD=Stomach adenocarcinoma, THCA=Thyroid carcinoma, UCEC=Uterine Corpus Endometrial Carcinoma. Wilcoxon test showing significance between tumor and adjacent tissue at * p<0.05, **p<0.01, ***p<0.001.