. Author manuscript; available in PMC: 2025 Jul 23.

Published in final edited form as: Physiol Rev. 2025 Jan 15;105(3):1291–1428. doi: 10.1152/physrev.00034.2023

Table 1.

Nomenclature, chromosomal location, and molecular dimensions of NOX genes and gene products

NOX	Other Names	NCBI Gene ID	# of transcripts^a	RefSeq Accession Number: mRNA,Protein^b	Chromosome Location^a,c	Gene Length	mRNA in bp	# Amino Acids	Molecular Mass	Coding mutations^d	Non-Coding mutations^d
NOX1	GP91–2, MOX1, NOH-1, NOH-1L, NOH1	27035	4	NM_007052, NP_008983	[-] Xq22.1; chrX:100,098,313–100,129,348	31036 bp	2543 bp	564	64871 Da	12	0
NOX2	AMCBX2, CGD, CGDX, GP91–1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX	1536	1	NM_000397, NP_000388	[+] Xp21.1-p11.4; chrX:37,639,312–37,672,714	33403 bp	4276 bp	570	65336 Da	768	160
NOX3	GP91–3, MOX-2	50508	1	NM_015718, NP_056533	[-] 6q25.3; chr6:155,395,368–155,455,839	60472 bp	1980 bp	568	64935 Da	6	0
NOX4	KOX, KOX-1, RENOX	50507	7	NM_001291927, NP_001278856.1	[-]11q14.3; chr11:89,324,353–89,589,557	265205 bp	4209 bp	578	66932 Da	4	1
NOX5		79400	3*	NM_024505, NP_078781	[+] 15q23; chr15:68,930,525–69,062,762	132238 bp	8405 bp	765	86439 Da	7	0
DUOX1	LNOX1, NOXEF1, THOX1	53905	2	NM_175940, NP_787954	[+] 15q21.1; chr15:45,129,933–45,165,576	35,644 bp	5483 bp	1551	177235 Da	44	3
DUOX2	LNOX2, P138(TOX), P138-TOX, THOX2	50506	2	NM_014080, NP_054799.4	[-]15q21.1; chr15:45,092,650–45,114,172	21523 bp	6361 bp	1548	175364 Da	450	52
p22^phox	CybA, Cytochrome B-245 Alpha Polypeptide; Cytochrome B(558) Alpha Chain	1535	1	NM_000101, NP_000092	[-] 16q24.2; chr16:88,643,275–88,651,083	7,809 bp	692 bp	195	21013 Da	89	20
p47^phox	Ncf1	653361	1	NM_000265, NP_000256	[+] 7q11.23 chr7:74,774,011–74,789,315	15,305 bp	1349 bp	390	44682 Da	55	8
NOXO1	SNX28; P41NOX; P41NOXA; P41NOXB; P41NOXC; SH3PXD5	124056	4	NM_172168, NP_751908	[-] 16p13.3; chr16:(1978917– 1981469)	5,276 bp	1556 bp	376	41253 Da	7	0
p67^phox	Ncf2; Neutrophil Cytosolic Factor 2	4688	5	NM_000433, NP_000424	[-] 1q25.3 chr1:183,554,461–183,601,849	47,389 bp	2267 bp	526	59762 Da	92	17
NOXA1	p67phox-Like Factor; NCF2-Like Protein	10811	3	NM_006647, NP_006638	[+] 9q34.3 chr9:137,423,350–137,434,406	11,057 bp	1678 bp	476	50933 Da	7	0
p40^phox	Ncf4; Neutrophil Cytosol Factor 4	4689	2	NM_013416, NP_038202	[+] 22q12.3 chr22:36,860,988–36,878,017	17,030 bp	1378 bp	339	39032 Da	12	5
DUOXA1	NIP; mol; NUMBIP	90527	7	NM_144565, NP_653166	[-] 15q21.1; chr15:45,117,366–45,129,938	12573 bp	1996 bp	343	37815 Da	5	1
DUOXA2	TDH5; SIMNIPHOM	405753	1	NM_207581.4, NP_997464	[+] 15q21.1; chr15:45,114,326–45,118,421	4096 bp	1755 bp	320	34787 Da	73	13

All information was collected from CBI-Gene card (https://www.genecards.org/) (1) unless otherwise indicated.

^a:

Isoform numbers correspond to # REFSEQ mRNAs as reported in GeneCards, numbers different from what is reported in the literature are marked with *.

^b:

RefSeq Accession Numbers for mRNA and protein of isoform selected by HGMD database.

^c:

Gene orientation on chromosome indicated in square parenthesis as positive or negative.

^d:

Number of mutations in coding and non-coding regions per HGMD.