Table 2.
Transcriptional regulators of NOXs.
| Subunit/Isoform | Transcription Factor | Cell Type | Transcriptional Effect | Reference |
|---|---|---|---|---|
|
| ||||
| NOX1 | ||||
|
| ||||
| STAT1 | Aortic Smooth Muscle | Upregulation | (1304) | |
| Colon Epithelial Cells | Upregulation | (747) | ||
| STAT3 | Aortic Smooth Muscle | Upregulation | (1304) | |
| Aortic Tissue | Upregulation | (861) | ||
| GATA4 | Colon Epithelial Cells | Upregulation | (1305) | |
| GATA6 | Colon Epithelial Cells | Upregulation | (1305) | |
| NFκB | Aortic Smooth Muscle | Upregulation | (1306) | |
| AP-1 | Aortic Smooth Muscle | Upregulation | (1307) | |
| Vascular Smooth Muscle | Upregulation | (1308) | ||
| MEF-2B | Vascular Smooth Muscle | Upregulation | (1308) | |
| Vascular Smooth Muscle | Upregulation | (1309) | ||
| C/EBPα | Aortic Smooth Muscle | Upregulation | (186) | |
| C/EBPβ | Aortic Smooth Muscle | Upregulation | (186) | |
| BMDM | Upregulation | (1310) | ||
| C/EBPδ | Aortic Smooth Muscle | Upregulation | (186) | |
| BMDM | Upregulation | (1310) | ||
| ATF-1 | Vascular Smooth Muscle | Upregulation | (1311) | |
|
| ||||
| NOX2 | ||||
|
| ||||
| NFκB | Monocytes, Microglia | Upregulation | (1312) | |
| Monocytes | Upregulation | (1313) | ||
| STAT3 | Aortic Tissue | Upregulation | (861) | |
| PPAR-α | Macrophages | Upregulation | (1314) | |
| HIF-1α | Microvascular Endothelial Cells | Upregulation | (447) | |
| CDP | HL60, HEL, PLB985 | Downregulation | (1315) | |
| CP1 | HL60, HEL, PLB985 | (1315) | ||
| YY1 | HeLa, K562, PLB985 | Upregulation | (1316) | |
| Elf-1 | PLB985, U937, Jurkat, K562 | Upregulation | (1317) | |
| PU.1 | PLB985, U937, Jurkat, K562 | Upregulation | (1317) | |
| Neutrophils, Mononuclear Leukocytes | Upregulation | (1318) | ||
| HeLa, U937 | Upregulation | (1319) | ||
| ICSBP | HeLa, U937 | Upregulation | (1319) | |
| IRF-1 | HL60, HeLa, PLB985 | (1320) | ||
| HeLa, U937 | Upregulation | (1319) | ||
| IRF-2 | HL60, HeLa, PLB985 | (1320) | ||
| HOXA9 | U937 | Upregulation | (1321) | |
| PBX1 | U937 | Upregulation | (1321) | |
| Meis1 | U937 | Downregulation | (1321) | |
| HOX10A | U937 | Downregulation | (1321) | |
|
| ||||
| p47 phox | ||||
|
| ||||
| NF-κB | Monocytes | Upregulation | (1313) | |
| AP-1 | Aortic Smooth Muscle | Upregulation | (1307) | |
| Ets-1 | Aortic Smooth Muscle | Upregulation | (1322) | |
| PPAR-α | Macrophages | Upregulation | (1314) | |
|
| ||||
| p67 phox | ||||
|
| ||||
| NFκB | Monocytes | Upregulation | (1313) | |
| AP-1 | Aortic Smooth Muscle | Upregulation | (1307) | |
| HL-60, PLB985 | Upregulation | (1323) | ||
| PPAR-α | Macrophages | Upregulation | (1314) | |
| Aortic Smooth Muscle | Upregulation | (1324) | ||
| PPAR-β/δ | Aortic Smooth Muscle | Upregulation | (1324) | |
| PPAR-γ | Aortic Smooth Muscle | Upregulation | (1324) | |
| PU.1 | HeLa, U937 | Upregulation | (1319) | |
| HL-60, PLB985 | Upregulation | (1323) | ||
| IRF1 | HeLa, U937 | Upregulation | (1319) | |
| ICSBP | HeLa, U937 | Upregulation | (1319) | |
|
| ||||
| p22 phox | ||||
|
| ||||
| NFκB | Aortic Smooth Muscle | Upregulation | (1325) | |
| C/EBPβ | Vascular Smooth Muscle | Upregulation | (1217) | |
|
| ||||
| NOX4 | ||||
|
| ||||
| HIF1α | Pulmonary Artery Smooth Muscle | Induced | (1326) | |
|
| ||||
| NFκB | Aortic Smooth Muscle | Induced | (1306) | |
| AP-1 | Aortic Smooth Muscle | Upregulation | (1307) | |
| STAT1 | Aortic Smooth Muscle | Upregulation | (1304) | |
| STAT3 | Aortic Smooth Muscle | Upregulation | (1304) | |
| Aortic Tissue | Upregulation | (861) | ||
| C/EBPα | Aortic Smooth Muscle | Upregulation | (186) | |
| C/EBPβ | Aortic Smooth Muscle | Upregulation | (186) | |
| C/EBPδ | Aortic Smooth Muscle | Upregulation | (186) | |
| E2F1 | Vascular Smooth Muscle | Upregulation | (1327) | |
| PPAR-α | Aortic Smooth Muscle | Upregulation | (1324) | |
| PPAR-β/δ | Aortic Smooth Muscle | Upregulation | (1324) | |
| PPAR-γ | Aortic Smooth Muscle | Upregulation | (1324) | |
| HUVEC | Downregulation | (1328) | ||
|
| ||||
| NOX5 | ||||
|
| ||||
| NFκB | Aortic Smooth Muscle | Upregulation | (1329) | |
| STAT1 | Aortic Smooth Muscle | Upregulation | (1329) | |
| STAT3 | Aortic Smooth Muscle | Upregulation | (1329) | |
| AP-1 | Aortic Smooth Muscle | Upregulation | (1329) | |
| C/EBPα | Aortic Smooth Muscle | Upregulation | (186) | |
| C/EBPβ | Aortic Smooth Muscle | Upregulation | (186) | |
| C/EBPδ | Aortic Smooth Muscle | Upregulation | (186) | |
| PPAR-α | Aortic Smooth Muscle | Upregulation | (1324) | |
| PPAR-β/δ | Aortic Smooth Muscle | Upregulation | (1324) | |
| PPAR-γ | Aortic Smooth Muscle | Upregulation | (1324) | |