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. 2025 Jul 23;11(30):eady2862. doi: 10.1126/sciadv.ady2862

Fig. 8. In vivo new bone formation in a rat calvarial bone defect model.

Fig. 8.

(A) Micro-CT images of calvaria defects with PLGA/HA, POC/HA, and BPLP-Gln-Mg/HA scaffolds at 6 and 12 weeks post-surgery. Scale bar, 1 mm. (B to E) Quantitative analysis of new bone formation at 6 (B and D) and 12 weeks (C and E). BV/TV, bone volume/tissue volume; BMD, bone marrow density. Data are average ± SD. One-way ANOVA with Tukey’s multiple comparisons test, *P < 0.05, ***P < 0.0005, ****P < 0.0001. n = 3. (F) H&E and Masson’s trichrome (MT) staining of calvaria bone samples at 6 and 12 weeks post-surgery. Scale bars, 1 mm (zoom out) and 50 μm (zoom in) (M, material; F, fibrosis tissue; NB, new bone).