Table 2. Summary of response and predictive markers from linear mixed models.

Notes: Problem-solving ability was measured using the SPSI; depression symptoms were measured using the SCL-20. BA, Brodmann area; DF, degree of freedom; MNI, Montreal Neurological Institute.

Regions	BA	Cluster (mm3)	F stat	DF1	DF2	z Score	P value	Coordinates in MNI space
I-CARE modifies cognitive control circuit mechanisms that are associated with improved problem-solving ability (hypothesis 1)
Left dLPFC	9	5504	24.79	1	147.35	4.64	<0.001	−28, 34, 36
Right IPL	48	3800	19.74	1	153.93	4.15	<0.001	54, −30, 28
PCUN	7	2693	24.93	1	150.85	4.65	<0.001	6, −58, 50
Left FFG	37	4248	25.31	1	154.21	4.69	<0.001	−30, −36, −22
Longitudinal changes in the cognitive control circuit are associated with longitudinal changes in depression symptoms at 6, 12, and 24 months (hypothesis 2)
Left AI	47	368	11.95	1	175.33	3.20	<0.001	−24, 24, −10
Right IPL	40/48	1064	11.86	1	175.98	3.19	<0.001	62, −52, 24
Left CdN	25	760	12.59	1	168.28	3.29	<0.001	−6, 8, 0
Longitudinal changes in the cognitive control circuit are associated with longitudinal changes in depression symptoms, as a function of time (hypothesis 2)
Right dLPFC	45/47	416	8.34	2	126.89	3.36	<0.001	50, 36, −4
Early cognitive control circuit changes at 2 months are associated with improved problem-solving ability at 6, 12, and 24 months (hypothesis 3)
Right IPL	48/40	864	18.72	1	69.92	3.89	<0.001	46, −46, 30
Left IPL	40	2360	14.06	1	69.11	3.38	<0.001	−48, −38, 50
Early cognitive control circuit changes at 2 months are associated with improved depression symptoms at 6, 12, and 24 months (hypothesis 3)
Right IPL	40/48	464	11.85	1	69.04	3.10	<0.001	49, −42, 30
Left SPL	7/40	872	14.25	1	70.53	3.41	<0.001	−26, −50, 50