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. Author manuscript; available in PMC: 2025 Jul 24.
Published in final edited form as: Sci Transl Med. 2024 Sep 4;16(763):eadh3172. doi: 10.1126/scitranslmed.adh3172

Table 3. Performance of circuit predictor models using 2-month cognitive control circuit changes to predict future improvements of treatment outcome for hypothesis 3.

Circuit model: using 2-month cognitive control circuit activity changes as well as baseline demographic and symptom characteristics as predictors to predict treatment outcomes at 6, 12, and 24 months. Baseline model: excluding 2-month cognitive control circuit measures and only including baseline demographic and symptom characteristics. Problem-solving ability was measured using the SPSI; depression symptoms were measured using the SCL-20. rp, Pearson correlation coefficient; MAE, mean absolute error.

Measure Problem-solving ability Depression symptoms

Baseline Circuit Baseline Circuit

rp (SD) 0.45 (0.12) 0.53 (0.13) 0.25 (0.09) 0.51 (0.14)
MAE (SD) 1.76 (0.18) 1.62 (0.26) 0.60 (0.10) 0.49 (0.07)
AIC (SD) 756.62 (21.25) 579.54 (13.69) 439.24 (14.81) 260.64 (14.71)
BIC (SD) 775.81 (21.40) 605.93 (10.79) 459.79 (14.74) 289.53 (15.64)