Table 5.
Mean ± SEM cytokine concentration (pg/mL) in synovial fluid
| Duration after injection (days) | |||||||
|---|---|---|---|---|---|---|---|
| Cytokine | Joint | 0 | 1 | 3 | 5 | 10 | 21 |
| IFNg | C | 426.6 ± 245.1 | 607 ± 421.6 | 661 ± 455.2 | 548.6 ± 308.3 | 600 ± 397.9 | 507.1 ± 343.2 |
| UC | 207.1 ± 41.4 | 515.4 ± 305.6 | 349.3 ± 133.7 | 292.8 ± 102.8 | 313.5 ± 92.1 | 307.8 ± 57.2 | |
| IL-1a | C | 947 ± 78.7 | 1015.5 ± 106.9 | 1119.9 ± 103.5 | 1168.3 ± 201.2 | 1160.6 ± 226.9 | 1266.9 ± 170.8 |
| UC | 973.7 ± 118.9 | 969.7 ± 130.2 | 1114.9 ± 172.4 | 969.9 ± 78.6 | 1106.5 ± 185.8 | 1086.5 ± 158.8 | |
| IL-1ra | C | 657.6 ± 225.1 | 8785.7 ± 2567.3 | 1767.6 ± 332.9 | 1294.1 ± 293.9 | 829.8 ± 322.2 | 687.9 ± 305.2 |
| UC | 437.8 ± 72.4 | 15,635.2 ± 5565.6 | 1625.6 ± 332.3 | 2418.1 ± 1260.6 | 729.9 ± 141.9 | 525.6 ± 91.9 | |
| IL-1ra/IL-1a | C | 0.7 ± 0.2 | 10.1 ± 3.6 | 1.6 ± 0.2 | 1.2 ± 0.3 | 0.6 ± 0.1 | 0.5 ± 0.1 |
| UC | 0.5 ± 0.1 | 16.4 ± 4.3 | 1.9 ± 0.5 | 3.2 ± 2.0 | 0.7 ± 0.1 | 0.5 ± 0.1 | |
| IL-2 | C | 1089.1 ± 116.3 | 1218.3 ± 201.3 | 1483.4 ± 254.3 | 1711.5 ± 337.5 | 1500.9 ± 282.4 | 1270.5 ± 202.5 |
| UC | 1072.9 ± 113.2 | 1125.8 ± 160.1 | 1317.6 ± 148.6 | 1295.6 ± 122.6 | 1501.6 ± 349.3 | 1250.5 ± 166.1 | |
| IL-4 | C | 272.4 ± 160.3 | 401.8 ± 290.0 | 477.3 ± 351.5 | 347.66 ± 199.7 | 309.4 ± 198.6 | 343.0 ± 247.0 |
| UC | 155.5 ± 47.9 | 339.1 ± 203.6 | 253.5 ± 133.7 | 191.9 ± 72.0 | 213.6 ± 75.1 | 203.5 ± 63.6 | |
| IL-8 | C | 867.5 ± 63.5 | 1099.3 ± 98.5 | 1046.9 ± 81.5 | 1483.8 ± 522.4 | 1484.8 ± 455.5 | 1150.4 ± 145.0 |
| UC | 872 ± 128.9 | 1169.8 ± 245.1 | 1439.1 ± 435.9 | 1131.3 ± 299.0 | 2934.6 ± 2061.1 | 1056.4 ± 162.8 | |
| IL-10 | C | 526.8 ± 166.8 | 824.7 ± 258.4 | 784.2 ± 334.8 | 764.8 ± 277.7 | 664.1 ± 297.8 | 643.8 ± 274.9 |
| UC | 411.3 ± 51.9 | 943.7 ± 266.0 | 546.3 ± 117.6 | 498.6 ± 83.3 | 515.0 ± 84.3 | 461.5 ± 61.4 | |
| IL-15 | C | 823.5 ± 104.1 | 959.8 ± 207.2 | 1169.8 ± 220.0 | 1294.4 ± 218.6 | 1192.4 ± 265.0 | 1049.6 ± 203.4 |
| UC | 759.8 ± 97.8 | 949.4 ± 194.0 | 1028.0 ± 142.1 | 1043.3 ± 107.9 | 1185.3 ± 238.6 | 938.3 ± 103.4 | |
| MCP-1 | C | 4874.9 ± 2119.5 | 10,265.3 ± 4536.8 | 7212.0 ± 3223.2 | 6810.6 ± 2438.1 | 4967.0 ± 1278.1 | 3629.6 ± 598.8 |
| UC | 5479.0 ± 2259.0 | 14,610.8 ± 4737.8 | 6471.8 ± 1933.9 | 7635.8 ± 2405.7 | 6312.1 ± 3016.4 | 3896.0 ± 1009.2 | |
| VEGF | C | 1608.5 ± 222.5 | 1617.9 ± 105.9 | 1630.2 ± 133.7 | 1583.4 ± 136.6 | 1747.3 ± 200.8 | 2001.3 ± 158.1 |
| UC | 1523.6 ± 259.9 | 1929.2 ± 252.7 | 1860.9 ± 197.3 | 1278.1 ± 116.3 | 1642.4 ± 281.5 | 1842.0 ± 238.0 | |