Table 7.
Trends in mean synovial fluid values in osteoarthritic joints injected with umbilical cord allograft
| Day 0 | Day 1 | Day 3 | Day 10 | Day 28 | |
|---|---|---|---|---|---|
| TNCC1 (cells/μL) | 150.0 | 9,000 | 2,400 | 250.0 | 200.0 |
| Albumin (g/dL) | 0.8 | 1.4 | 1.2 | 0.8 | 1.0 |
| Globulin (g/dL) | 0.4 | 1.2 | 0.7 | 0.6 | 0.4 |
| IL-1a | 1386.5 | 1204.0 | 1160.0 | 1271.0 | 1314.5 |
| IL-1ra | 429.0 | 4926.0 | 2086.0 | 447.5 | 636.5 |
| IL-1ra/IL-1a | 0.3 | 4.1 | 1.8 | 0.4 | 0.5 |
| IL-10 | 280.0 | 529.5 | 493.5 | 328.0 | 353.5 |
| VEGF | 1535.5 | 1905.5 | 2253.0 | 1641.5 | 1850.5 |
| HA | 127.7 | 301.2 | 303.4 | 175.0 | 122.7 |
| IFNg | 215.0 | 209.5 | 200.5 | 205.5 | 309.0 |
| IL-2 | 1095.0 | 1131.0 | 1161.0 | 1198.0 | 1202.5 |
| IL-4 | 147.0 | 142.0 | 125.0 | 117.5 | 462.5 |
| IL-8 | 1039.0 | 2017.0 | 1105.5 | 1017.5 | 1173.0 |
| IL-15 | 882.5 | 863.5 | 766.5 | 842.5 | 1028.0 |
| MCP-1 | 2082.5 | 2514.0 | 5071.0 | 1887.5 | 1965.0 |
1TNCC total nucleated cell count (cells/μL); normal range is < 1000 TNCC/μL; see abbreviations in Table 3 for cytokines
Total protein values < 2.0 g/dL are within acceptable limits, however, typically are ≤ 1.5 g/dL in synovial fluid. Values ranging from 2.0 to 4.5 gm/dL reflect a transudate, and over 4.5 g/dL reflect an exudate
Normal synovial fluid values for albumin are < 1.2 g/dL and for globulin are < 3.3 g/dL