Table 3.
Registered clinical trials evaluating maintenance therapies in MOGAD. Information per clinicaltrials.gov
| Clinical trial | Treatment | Comparator | Inclusion criteria | Primary outcome |
|---|---|---|---|---|
| IDAR (NCT05545384) | Azathioprine or rituximab | No maintenance treatment | Following first attack | Annualized relapse rate at 24 months |
| MOGwAI (NCT05349006) | Azathioprine with steroid taper | Steroid taper | Following first attack | Time to first relapse |
| cosMOG (NCT05063162) | Rozanolixizumab | Placebo | Relapsing course with ≥l relapse in 12 months | Time to first relapse |
| METEROID(NCT05271409) | Satralizumab (allows concomitant azathioprine or mycophenolate mofetil) | Placebo | Relapsing course with ≥l relapse in 12 months or ≥2 relapses in 24 months | Time to first relapse |