. Author manuscript; available in PMC: 2025 Jul 24.

Published in final edited form as: Breast Cancer Res Treat. 2025 Jul 6;213(1):115–126. doi: 10.1007/s10549-025-07764-w

Table 1.

Definitions of comorbidity

Comorbidity	Definition
Renal Impairment	Creatinine Clearance^a < 30mL/min
Hepatic Impairment^b	Total Bilirubin > 1.5mg/dL OR AST > 3 times ULN OR ALT > 3 times ULN OR ALP > 2.5 times ULN
Neutropenia	Absolute Neutrophil Count < 1500μL OR ICD-9: 288.0^, 288.5^ OR ICD-10: D70^, D72.81^
Thrombocytopenia	Platelets < 100,000μL OR ICD-9: 287.3^, 287.4^, 287.5, 289.84, 99.05 OR ICD-10: D47.3, D69.3, D69.4^, D69.5^, D69.6, D75.82^*, 30233R1, 30243R1

Creatinine Clearance was calculated by using serum creatinine and weight, with the Cockroft-Gault Equation (Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi:10.1159/000180580).

AST: aspartate transaminase; ALT: alanine transaminase; ALP: alkaline phosphatase; ULN: upper limit of normal

All sub-codes were included