TABLE 1 ∣.
Number and incidencea of invasive fungal diseases among solid organ or hematopoietic cell transplant recipients, by transplant type, United States, 2018–2022.
| IFD type | Solid organ | Hematopoietic cell | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||
| Total (n = 9143) |
Kidneyb (n = 5667) |
Liverc (n = 2025) |
Heart (n = 759) |
Lungd (n = 650) |
Pancrease (n = 39) |
Total (n = 5693) |
Autologous (n = 3519) |
Allogeneic (n = 2114) |
Unspecified allogeneic or autologous (n = 60) |
|
| Any IFD | 360 (21.0) | 138 (12.6) | 67 (18.7) | 35 (24.8) | 117 (105.3) | 3 (41.2) | 292 (28.5) | 85 (12.8) | 205 (58.4) | 2 (18.7) |
| Mold infections | 121 (7.1) | 32 (2.9) | 12 (3.4) | 11 (7.8) | 66 (59.4) | 0 (0) | 69 (6.7) | 13 (2.0) | 56 (16.0) | 0 (0) |
| Aspergillosis | 115 (6.7) | 28 (2.6) | 11 (3.1) | 10 (7.1) | 66 (59.4) | 0 (0) | 57 (5.6) | 9 (1.4) | 48 (13.7) | 0 (0) |
| Mucormycosis | 7 (0.4) | 4 (0.4) | 2 (0.6) | 1 (0.7) | 0 (0) | 0 (0) | 13 (1.3) | 4 (0.6) | 9 (2.6) | 0 (0) |
| Candidiasis | 48 (2.8) | 16 (1.5) | 13 (3.6) | 3 (2.1) | 15 (13.5) | 1 (13.7) | 33 (3.2) | 10 (1.5) | 23 (6.6) | 0 (0) |
| Endocarditis | 2 (0.1) | 1 (0.1) | 0 (0) | 0 (0) | 1 (0.9) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Enteritis | 3 (0.2) | 1 (0.1) | 2 (0.6) | 0 (0) | 0 (0) | 0 (0) | 1 (0.1) | 0 (0) | 1 (0.3) | 0 (0) |
| Meningitis | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Pulmonary infection | 19 (1.1) | 4 (0.4) | 1 (0.3) | 3 (2.1) | 11 (9.9) | 0 (0) | 12 (1.2) | 4 (0.6) | 8 (2.3) | 0 (0) |
| Sepsis | 26 (1.5) | 11 (1.0) | 10 (2.8) | 0 (0) | 4 (3.6) | 1 (13.7) | 21 (2.1) | 6 (0.9) | 15 (4.3) | 0 (0) |
| Endemic mycoses | 56 (3.3) | 25 (2.3) | 19 (5.3) | 7 (5.0) | 5 (4.5) | 0 (0) | 12 (1.2) | 8 (1.2) | 4 (1.1) | 0 (0) |
| Blastomycosis | 2 (0.1) | 1 (0.1) | 0 (0) | 1 (0.7) | 0 (0) | 0 (0) | 1 (0.1) | 1 (0.2) | 0 (0) | 0 (0) |
| Histoplasmosis | 31 (1.8) | 15 (1.4) | 11 (3.1) | 2 (1.4) | 3 (2.7) | 0 (0) | 6 (0.6) | 4 (0.6) | 2 (0.6) | 0 (0) |
| Coccidioidomycosis | 23 (1.3) | 9 (0.8) | 8 (2.2) | 4 (2.8) | 2 (1.8) | 0 (0) | 5 (0.5) | 3 (0.5) | 2 (0.6) | 0 (0) |
| Cryptococcosis | 27 (1.6) | 17 (1.6) | 5 (1.4) | 2 (1.4) | 3 (2.7) | 0 (0) | 1 (0.1) | 0 (0) | 1 (0.3) | 0 (0) |
| Pneumocystosis | 32 (1.9) | 16 (1.5) | 9 (2.5) | 3 (2.1) | 4 (3.6) | 0 (0) | 78 (7.6) | 31 (4.7) | 46 (13.1) | 1 (9.4) |
| Other specified | 22 (1.3) | 7 (0.6) | 5 (1.4) | 1 (0.7) | 9 (8.1) | 0 (0) | 23 (2.2) | 5 (0.8) | 18 (5.1) | 0 (0) |
| Unspecified | 67 (3.9) | 28 (2.6) | 9 (2.5) | 11 (7.8) | 17 (15.3) | 2 (27.5) | 85 (8.3) | 20 (3.0) | 64 (18.3) | 1 (9.4) |
Abbreviation: IFD, invasive fungal disease.
Incidence displayed as the number of patients with IFD (incidence per 1000 person-years). Patients could have been diagnosed with more than one IFD type on the same day. In addition to IFDs displayed in the table, one case of sporotrichosis and one case of eumycetoma were identified, both in lung transplant patients. No patients had chromoblastomycosis or paracoccidioidomycosis. No IFDs were identified in 3 intestine transplant recipients.
Includes 56 kidney/heart, 195 kidney/pancreas.
Includes 14 liver/heart, 116 liver/kidney, 7 liver/lung, 4 liver/pancreas/intestine.
Includes 8 lung/heart, 5 lung/kidney.
Includes 3 pancreas/intestine.