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. 2025 Jul 24;9:254. doi: 10.1038/s41698-025-01053-x

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Xenograted tumor development of indicated EC cell lines in immunodeficient female NRG mice (n = 4). Tumorigenicity, capability to induce tumor formation; latency, time intervals (days) between cell inoculation and measurable tumor size (~100 mm³)”; doubling time, days for tumor volume increasing from ~200 to 400 mm³. Error bars represent SD. b Histology and immunohistochemical features of xenograft tumors of MMRd EC cell lines. c Histology and immunohistochemical features of xenograft tumors of p53abn EC cell lines.