Table 2.
Potential drug target evaluation results.
| Target | Binding site features | Drug score | Accessibility | Physicochemical properties | Overall assessment |
|---|---|---|---|---|---|
| Core NTD | Volume: 950 ų | 0.78 | 0.85 | MW: 21 kDa | Promising |
| Enclosure: 0.82 | Hydrophobicity: −0.35 | ||||
| NS3 | Volume: 1250 ų | 0.85 | 0.92 | MW: 70 kDa | Highly Promising |
| Protease | Enclosure: 0.90 | Hydrophobicity: −0.20 | |||
| NS5A | Volume: 1100 ų | 0.80 | 0.88 | MW: 56 kDa | Promising |
| Domain I | Enclosure: 0.85 | Hydrophobicity: −0.15 | |||
| NS5B | Volume: 1400 ų | 0.90 | 0.95 | MW: 66 kDa | Highly Promising |
| Polymerase | Enclosure: 0.92 | Hydrophobicity: −0.25 | |||
| E2 | Volume: 800 ų | 0.72 | 0.80 | MW: 70 kDa | Moderately |
| HVR1 | Enclosure: 0.75 | Hydrophobicity: −0.05 | Promising |