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. 2002 Apr 30;99(9):6118–6123. doi: 10.1073/pnas.092595699

Figure 4.

Figure 4

The consequences of an intron-expansion event for the coding sequence of two flanking exons. (Upper) Regardless of the intron phase, a 2-nucleotide (or 1-nucleotide) expansion will result in a frameshift in all downstream codons. (Lower) A 3-nucleotide expansion results in the loss of a codon if the intron is in phase 0, but a loss of a codon plus one altered codon sequence if the intron is in phase 1 or 2.

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