Table 3.
Characteristic of anesthesia and surgery in patients receiving remimazolam combined with or without remifentanil for anaesthesia induction.
| Parameters | Normal saline group (n = 84) | Remifentanil-1 group (n = 85) | Remifentanil-2 group (n = 82) | p value |
|---|---|---|---|---|
| Total administration of remimazolam; mg | 24.5 (20.6, 29.5) | 23.2 (20.6, 29.6) | 20.7 (17.5, 26.5)#, * | <0.001 |
| Total administration of remifentanil; μg | 113.0 (81.5, 152.7) | 108.0 (90.3, 158.8) | 149.3 (108.3, 192.9)##, *** | <0.001 |
| Duration of surgery; min | 16.2 (11.0, 22.9) | 16.4 (13.5, 25.0) | 17.0 (11.5, 25.0) | 0.462 |
| Duration of anaesthesia; min | 26.0 (17.8, 34.4) | 27.3 (19.0, 34.0) | 26.1 (19.1, 39.4) | 0.702 |
| Time from drug withdrawal to opening eyes; min | 6.7 (5.0, 8.4) | 6.0 (4.0, 7.0) | 5.0 (4.0, 7.6) | 0.011 |
| Ramsay scores at 15 min after surgery | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 0.442 |
| NRS before leaving PACU | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | 1.0 (1.0, 1.0) | >0.999 |
| Crystalloid infusion volume; ml | 100.0 (100.0, 120.0) | 100.0 (100.0, 100.0) | 100.0 (100.0, 150.0) | 0.408 |
NRS, numerical rating scale; PACU, post-anesthesia care unit.
Values are presented as median (IQR). #p < 0.05, ##p < 0.01, compared with the normal saline group; *p < 0.05, ***p < 0.001, compared with the Remifentanil-1 group.