Table 10.
Significant differences in partial correlations between steroid pairs in myalgic Encephalomyelitis / Chronic fatigue syndrome and control groups
| Steroid 1 | Steroid 2 | r ME/CFS | r CTRL | Z statistic | p value | CI Lower | CI Upper | q value |
|---|---|---|---|---|---|---|---|---|
| 17α-Hydroxyprogesterone (17OHP) | Pregnenolone (PNL) | 0.534 | -0.757 | 5.136 | 0.000 | 0.848 | 1.562 | 0.000 |
| Androstenedione (Andro) | Androstenedione (AED) | 0.168 | -0.852 | 4.643 | 0.000 | 0.567 | 1.396 | 0.000 |
| Androstenedione (Andro) | Progesterone (P4) | -0.102 | 0.854 | -4.455 | 0.000 | -1.349 | -0.509 | 0.000 |
| Aldosterone (Aldo) | 17α-Hydroxyprogesterone (17OHP) | 0.091 | -0.830 | 4.145 | 0.000 | 0.465 | 1.318 | 0.001 |
| Androstenedione (AED) | Dehydroepiandrosterone (DHEA) | -0.013 | 0.850 | -4.118 | 0.000 | -1.273 | -0.424 | 0.001 |
| Dehydroepiandrosterone (DHEA) | Progesterone (P4) | 0.071 | -0.821 | 3.990 | 0.000 | 0.434 | 1.294 | 0.001 |
| Androsterone (ADT) | Dehydroepiandrosterone (DHEA) | 0.645 | 0.960 | -3.817 | 0.000 | -0.635 | -0.121 | 0.003 |
| Androsterone (ADT) | Pregnenolone (PNL) | -0.051 | 0.797 | -3.703 | 0.000 | -1.258 | -0.384 | 0.004 |
| Aldosterone (Aldo) | Progesterone (P4) | 0.287 | -0.679 | 3.637 | 0.000 | 0.451 | 1.339 | 0.004 |
| 11-Deoxycorticosterone (DOC) | Pregnenolone (P5) | -0.469 | 0.548 | -3.642 | 0.000 | -1.368 | -0.486 | 0.004 |
| Androsterone (ADT) | Aldosterone (Aldo) | -0.111 | 0.746 | -3.481 | 0.001 | -1.262 | -0.367 | 0.006 |
| Corticosterone (B) | 17α-Hydroxyprogesterone (17OHP) | -0.231 | 0.684 | -3.475 | 0.001 | -1.303 | -0.400 | 0.006 |
| Dehydroepiandrosterone (DHEA) | Corticosterone (B) | -0.002 | 0.787 | -3.456 | 0.001 | -1.209 | -0.327 | 0.006 |
| Androsterone (ADT) | Corticosterone (B) | -0.178 | -0.845 | 3.432 | 0.001 | 0.263 | 1.097 | 0.006 |
| Estradiol (E2) | 17α-Hydroxyprogesterone (17OHP) | 0.533 | -0.427 | 3.405 | 0.001 | 0.418 | 1.329 | 0.006 |
| Aldosterone (Aldo) | Corticosterone (B) | -0.342 | 0.586 | -3.334 | 0.001 | -1.308 | -0.389 | 0.006 |
| Androsterone (ADT) | 11-Deoxycortisol (11DOC) | -0.315 | 0.610 | -3.351 | 0.001 | -1.306 | -0.389 | 0.006 |
| Cortisol (F) | 11-Deoxycorticosterone (DOC) | -0.691 | 0.182 | -3.351 | 0.001 | -1.272 | -0.361 | 0.006 |
| Estradiol (E2) | Progesterone (P4) | 0.372 | -0.565 | 3.338 | 0.001 | 0.394 | 1.313 | 0.006 |
| 11-Deoxycorticosterone (DOC) | 17α-Hydroxyprogesterone (17OHP) | 0.634 | -0.254 | 3.265 | 0.001 | 0.357 | 1.281 | 0.007 |
| Dehydroepiandrosterone (DHEA) | Cortisol (F) | 0.073 | -0.709 | 3.107 | 0.002 | 0.283 | 1.202 | 0.012 |
| Androsterone (ADT) | 17α-Hydroxyprogesterone (17OHP) | 0.134 | 0.783 | -2.977 | 0.003 | -1.085 | -0.210 | 0.018 |
| Aldosterone (Aldo) | Cortisol (F) | 0.538 | -0.293 | 2.923 | 0.003 | 0.274 | 1.236 | 0.018 |
| Androstenedione (AED) | Estradiol (E2) | -0.287 | 0.543 | -2.926 | 0.003 | -1.235 | -0.275 | 0.018 |
| Corticosterone (B) | Progesterone (P4) | 0.384 | 0.864 | -2.935 | 0.003 | -0.894 | -0.144 | 0.018 |
| Testosterone (T) | Cortisone (Cot) | 0.309 | -0.531 | 2.952 | 0.003 | 0.284 | 1.243 | 0.018 |
| Testosterone (T) | 11-Deoxycorticosterone (DOC) | -0.239 | 0.570 | -2.891 | 0.004 | -1.221 | -0.260 | 0.019 |
| 17α-Hydroxyprogesterone (17OHP) | Progesterone (P4) | -0.025 | -0.696 | 2.704 | 0.007 | 0.178 | 1.109 | 0.033 |
| Androstenedione (AED) | 17α-Hydroxyprogesterone (17OHP) | 0.061 | 0.707 | -2.654 | 0.008 | -1.086 | -0.162 | 0.037 |
| Corticosterone (B) | 11-Deoxycorticosterone (DOC) | 0.694 | 0.042 | 2.639 | 0.008 | 0.161 | 1.093 | 0.038 |
| Dehydroepiandrosterone (DHEA) | 11-Deoxycortisol (11DOC) | 0.070 | -0.629 | 2.624 | 0.009 | 0.172 | 1.135 | 0.038 |
| Corticosterone (B) | Pregnenolone (P5) | 0.382 | -0.377 | 2.591 | 0.010 | 0.183 | 1.183 | 0.041 |
| Aldosterone (Aldo) | 11-Deoxycorticosterone (DOC) | 0.213 | -0.521 | 2.574 | 0.010 | 0.172 | 1.164 | 0.041 |
| Aldosterone (Aldo) | Pregnenolone (PNL) | -0.324 | -0.805 | 2.516 | 0.012 | 0.099 | 0.910 | 0.045 |
| Corticosterone (B) | Estradiol (E2) | -0.039 | 0.626 | -2.508 | 0.012 | -1.107 | -0.141 | 0.045 |
| Dehydroepiandrosterone (DHEA) | Pregnenolone (PNL) | -0.175 | -0.740 | 2.503 | 0.012 | 0.116 | 1.008 | 0.045 |
| Etiocholanolone (Etn) | Pregnenolone (PNL) | 0.447 | -0.289 | 2.523 | 0.012 | 0.161 | 1.166 | 0.045 |
| Cortisol (F) | Estradiol (E2) | 0.032 | -0.616 | 2.434 | 0.015 | 0.122 | 1.094 | 0.053 |
| Pregnenolone (PNL) | Progesterone (P4) | 0.037 | -0.612 | 2.430 | 0.015 | 0.121 | 1.095 | 0.053 |
| Cortisol (F) | 17α-Hydroxyprogesterone (17OHP) | 0.245 | -0.429 | 2.296 | 0.022 | 0.095 | 1.119 | 0.074 |
| 11-Deoxycortisol (11DOC) | 17α-Hydroxyprogesterone (17OHP) | 0.292 | -0.376 | 2.253 | 0.024 | 0.083 | 1.114 | 0.081 |
| Etiocholanolone (Etn) | Testosterone (T) | 0.116 | 0.665 | -2.219 | 0.026 | -1.002 | -0.060 | 0.086 |
| Androsterone (ADT) | Cortisol (F) | 0.219 | 0.713 | -2.173 | 0.030 | -0.942 | -0.044 | 0.090 |
| Androsterone (ADT) | Pregnenolone (P5) | 0.025 | -0.569 | 2.175 | 0.030 | 0.055 | 1.051 | 0.090 |
| Corticosterone (B) | 11-Deoxycortisol (11DOC) | -0.107 | 0.514 | -2.187 | 0.029 | -1.075 | -0.060 | 0.090 |
| Aldosterone (Aldo) | Pregnenolone (P5) | 0.216 | 0.705 | -2.128 | 0.033 | -0.938 | -0.035 | 0.094 |
| Androstenedione (AED) | Cortisone (Cot) | 0.624 | 0.074 | 2.129 | 0.033 | 0.040 | 1.008 | 0.094 |
| Dehydroepiandrosterone (DHEA) | Estradiol (E2) | -0.038 | -0.603 | 2.140 | 0.032 | 0.043 | 1.024 | 0.094 |
| Androstenedione (AED) | Progesterone (P4) | 0.237 | 0.712 | -2.104 | 0.035 | -0.924 | -0.029 | 0.098 |
| Etiocholanolone (Etn) | Cortisol (F) | -0.197 | 0.414 | -2.074 | 0.038 | -1.070 | -0.029 | 0.104 |
| Androstenedione (AED) | Pregnenolone (P5) | 0.081 | -0.505 | 2.062 | 0.039 | 0.025 | 1.047 | 0.105 |
| Cortisone (Cot) | Estrone (E1) | -0.623 | -0.098 | -2.044 | 0.041 | -0.985 | -0.018 | 0.107 |
| Androstenedione (AED) | Pregnenolone (PNL) | 0.183 | 0.667 | -2.011 | 0.044 | -0.941 | -0.009 | 0.114 |
| Cortisol (F) | 11-Deoxycortisol (11DOC) | 0.190 | -0.395 | 1.976 | 0.048 | 0.000 | 1.050 | 0.121 |
| Cortisol (F) | Pregnenolone (P5) | -0.395 | 0.185 | -1.957 | 0.050 | -1.046 | 0.005 | 0.121 |
| Cortisol (F) | Progesterone (P4) | -0.340 | -0.743 | 1.953 | 0.051 | -0.003 | 0.839 | 0.121 |
| Pregnenolone (P5) | Progesterone (P4) | -0.003 | 0.539 | -1.963 | 0.050 | -1.009 | 0.003 | 0.121 |
Adjusted p value; FDR = BH q < 0.05