Table 1.

Twenty-five cRegulons for human fetal atlas, as well as their top TFs and enriched biological functions

	cRegulon	Top TFs	Enriched functions
Neural state	M1	FOXG1, RFX4, NEUROD2, NEUROG2, ASCL1, ESRRB	Neural progenitor state
	M2	PAX3, RFX4, POU3F2/F3, OLIG1, NEUROD2, PAX6	Postmitotic early neuron
	M3	TFAP2A, LHX-, POU3F2, OLIG, EN-	Postmitotic late neuron
	M4	VAX-, RAX-, VSX-, NEUROD/G-, PAX6	Ocular development
	M5	OLIG1/2/3, PAX6, NR2E1, VAX1, SOX8, SOX9, GLI3	Neuroglia
	M6	TFAP2B, SOX11, ASCL1, PHOX2B, PHOX2A	Sympathetic system
	M7	NEUROD1, HNF1A, FOXA2	Neuroendocrine system
	M8	HMX3, NEUROG1, POU4F2, DBX2	Neuromuscular system
Pancreatic state	M9	HNF4A, HES1, PROX1, HNF1A, ONECUT1, GATA6, PDX1	Pancreas exocrine
	M10	GATA6, INSM1	Pancreas endocrine
Hemopoiesis and immunity	M11	MAFB, SIX4, SIX1, TCF7, LEF1, STAT4	Immune cells
	M12	STAT5B, TAL1, GATA2, GATA1	Hemopoiesis
	M13	IRF4, IRF1, IRF7, IRF8, IRF5, IRF9	Cytokine signals
Muscular state	M14	FOXF1, TBX18, NFATC4, TBX2, HLX, NR2F2, MSC, MEOX2	Muscle organ development
	M15	MYOG, TBX1, MYOD1, MYF6, MYF5	Muscle structure
Mes-endoderm state	M16	HOX-, WT1, FOXC2, GLI3, ARID5B, TCF21, GLI2	AP pattern of internal organs
	M17	HOX-, HEY2, TBX3, NFATC4, TBX2	AP pattern of skeleton and muscle
	M18	CEBPA, XBP1, ONECUT2, HNF4A, ONECUT1, HNF1A, NR1H3, PPARG	Lipid-glucose homeostasis and transport activity
	M19	FOXB1, PAX8, PAX2	Kidney development
	M20	OSR2, HLX, MYC, TWIST1, TWIST2, MSX1, FOXO4	Adrenal gland
	M21	CEBPA, CEBPB, EPAS1, GATA2, DLX-	Placental development
	M22	FOXC1, EPAS1, TAL1, ID1, MEOX2, ELK3	Angiogenesis
Epi-endothelial state	M23	AIRE, FOXN1, PRDM1, SPDEF	Epithelium transport
	M24	JUN-, FOS-, FOXA1, SOX9, GRHL2, RREB1	Epithelium structure
	M25	JUN-, FOS-, FOXC1, KLF5, ID1, HOXB3, MEOX2	Endothelium