Given a cell type in which strength of M1 is$s_1$and the strength of M2 is$s_2$

For${\mathit{TF}}_i-{\mathit{TG}}_j$in M1:

With P=$s_1$ $R_{\mathit{ij}}$is preserved

with P = 1-$s_1$ $R_{\mathit{ij}}\sim U\left(\text{0,1}\right)$

For${\mathit{TF}}_i-{\mathit{TG}}_j$in M2:

With P=$s_2$ $R_{\mathit{ij}}$is preserved

with P = 1-$s_2$ $R_{\mathit{ij}}\sim U\left(\text{0,1}\right)$