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. 2002 Apr 23;99(9):6181–6186. doi: 10.1073/pnas.092141999

Figure 3.

Figure 3

Cosecretion of ATAC, MIP-1α, MIP-1β, RANTES, and IFN-γ by antigen-specific CD8+ T cells during the adaptive phase of L. monocytogenes infection. BALB/c mice were infected with a sublethal dose of L. monocytogenes. On day 7 (d7) p.i. of primary infection or day 5 (d5) p.i. of a secondary infection, splenocytes of individual mice were restimulated with the Listeria-specific peptide LLO91–99 for 6 h in the presence of brefeldin A. Cells were stained for CD8, fixed, and counterstained for IFN-γ, ATAC, MIP-1α, MIP-1β, or RANTES. (A) Cosecretion of IFN-γ with ATAC by Listeria-specific CD8+ T cells in primary and secondary infection. (B) Cosecretion of IFN-γ and ATAC with MIP-1α, MIP-1β, and RANTES by Listeria-specific CD8+ T cells in secondary infection. Analysis of one representative animal out of six is shown.