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. 2002 Apr 16;99(9):6216–6221. doi: 10.1073/pnas.082011999

Figure 2.

Figure 2

β-Glucuronidase expression after FIV-mediated gene transfer. (A) Transgene-positive cells near the region of the injection as revealed by in situ RNA analyses. (B) β-Glucuronidase activity in the brain of a MPS VII mouse injected with FIVβgluc and stained for β-glucuronidase activity (dark red reaction product). (C, E, and G) Representative examples of the lysosomal storage in the striatum (C), cortex (E) and hippocampus (G) of 8- to 12-week-old MPS VII mice. (D, F, and H) Correction of the storage defect in the contralateral striatum (D), cortex (F) and hippocampus (H) 6 weeks after injection of FIVβgluc into an 8-week-old MPS VII mouse.