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. 2002 Apr 23;99(9):6234–6239. doi: 10.1073/pnas.092637699

Figure 1.

Figure 1

Histological and histomorphometric analysis of myocardium. (A) Trichrome stain of myocardium of wild-type mice (ctsl+/+) and CTSL-deficient mice (ctsl−/−) at 12 months of age. Connective tissue appears in blue. (B) Large pleomorphic nucleus (P) in CTSL-deficient myocardium as compared with a normal nucleus (N). Masson's trichrome stain at 100-fold resolution. Note the distinct interstitial collagen staining in the absence of CTSL. (C) Histomorphometric determination of left ventricular connective tissue of wild-type (black) and CTSL-deficient (gray) mice. (D) Numeric density of nuclei in cardiomyocytes of wild-type (black) and CTSL-deficient (gray) ventricles. (a) P < 0.001 for comparison of wild-type (10 females, seven males) and knockout (nine females, five males) mice.