Table 2.
Correlation between stage of pregnancy and spatial distribution of PrPSc in placentomes of pregnant scrapie-infected ewes
| PrPSc | Stage of pregnancy
|
||
|---|---|---|---|
| Early (n = 7) | Mid (n = 1) | Term (n = 2) | |
| Pattern of PrPSc distribution | Numerous small plaques in multinucleate cells | Mostly small plaques and few large plaques | Primarily large plaques spanning several villi |
| Location of PrPSc plaque | Maternal crypts of zone A | Primarily maternal crypt of zone A and some in zone B | Primarily zone C |
PrPSc was defined by immunohistochemistry. Early pregnancy, days 40–60 post mating; mid-pregnancy, days 80–100 post mating; term pregnancy, days 140–150 post mating.