Table 3.
Effects of SSR149415 and diazepam on several behavioral responses displayed by mice before (line crossings) and during (chase speed, avoidance, and risk assessment) exposure to a Long Evans rat in the Mouse Defense Test battery
| Compound | Dose, mg/kg | Activity
|
Flight: avoidance distance, cm | Risk assessment
|
||
|---|---|---|---|---|---|---|
| Line crossings | Chase speed, m/s | Stops | Approaches-withdrawals | |||
| Diazepam | 0 | 114.8 ± 12.1 | 0.8 ± 0.1 | 165.8 ± 16.6 | 13.8 ± 1 | 0.2 ± 0.2 |
| (i.p.) | 0.5 | 153.8 ± 12.7 | 0.7 ± 0.1 | 131.7 ± 21.6 | 7.3 ± 1.6* | 0.5 ± 0.2 |
| 1 | 135.8 ± 9.7 | 0.8 ± 0.1 | 122.7 ± 23.1 | 7.5 ± 1.4* | 1.5 ± 0.4* | |
| 3 | 122.2 ± 21 | 0.6 ± 0.1 | 106.5 ± 20 | 4 ± 1.5* | 1.2 ± 0.5* | |
| SSR149415 | 0 | 101.3 ± 9.7 | 0.9 ± 0.1 | 176.8 ± 12.6 | 11.1 ± 0.7 | 0 ± 0 |
| (p.o.) | 1 | 127.8 ± 8.2 | 0.8 ± 0.1 | 137.5 ± 11.7 | 8.8 ± 1 | 0 ± 0 |
| 3 | 122.1 ± 13.7 | 0.8 ± 0.1 | 151 ± 4.3 | 8.1 ± 1.1 | 0 ± 0 | |
| 10 | 119.7 ± 5.4 | 0.8 ± 0.1 | 152.4 ± 14.5 | 9.6 ± 0.5 | 0.1 ± 0.1 | |
| 30 | 122.7 ± 10.5 | 0.8 ± 0.1 | 121.6 ± 11.9* | 8.3 ± 1 | 0 ± 0 | |
Data represent mean ± SEM.
*
, P < 0.05 (Dunnett's t test). n = 6–9.