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. 2002 Apr 23;99(9):6376–6381. doi: 10.1073/pnas.082127599

Figure 1.

Figure 1

Strongly diminished responses in trp2−/− vomeronasal sensory neurons to synthetic and natural stimuli. (A) Representative EVG responses from wild-type (Upper) and trp2−/− mice (Lower). Responses were induced by 500-ms pulses of 2-heptanone at 10−7 M or 10−4 M, respectively. (B) Representative EVG responses from wild-type (Upper) and trp2−/− mice (Lower) induced by 500-ms pulses of urine diluted 1/105 or 1/102, respectively. (C) Histograms showing collected results (mean ± SD) from +/+ (red), +/− (green), and −/− (blue) mice. Peak EVG responses from male and female animals were pooled. For stimulation with 10−7 M 2-heptanone, no responses are observed in trp2 mutants (n = 11). With 10−4 M 2-heptanone, responses are reduced to about 25% of control mice [+/+: 305 ± 66 μV (n = 7); trp2−/−: 77 ± 15 μV (n = 4); P < 0.0001]. For stimulation with urine diluted 1/105, no responses are observed in trp2 mutants (n = 4). With urine diluted 1/102, responses are reduced to about 37% of control mice [+/+: 277 ± 61 μV (n = 6); trp2−/−: 103 ± 45 μV (n = 10); P < 0.0001]. Responses from +/+ and +/− mice were essentially identical (P = 0.21–0.80).