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. 2002 Apr 30;99(9):6386–6391. doi: 10.1073/pnas.092129699

Figure 4.

Figure 4

AP firing is required for regulated BDNF secretion. (A) BDNF secretion in response to trains of 250 pulses at 50 Hz in absence (n = 17) and presence (n = 22) of 1 μM TTX. BDNF secretion measured in supernatants collected over 5 min was completely abolished if APs were blocked. Values given represent the mean ± SE. n.s., Not significant (P > 0.05). (B) Patch clamp recordings in current clamp mode of hippocampal neurons under the same conditions as in A. TTX (1 μM) abolished the formation of APs in response to field stimulation. One stimulus in presence and in absence of TTX is enlarged.