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. 2025 Jul 19;26(14):6937. doi: 10.3390/ijms26146937
DM diabetes mellitus
DM1 type 1 DM
DM2 type 2 DM
CVD cardiovascular disease
SGLTs sodium–glucose cotransporter
RAAS renin–angiotensin–aldosterone system
1,5-AG 1,5-anhydroglucitol
EDKA euglycemic diabetic ketoacidosis
HMG-CoA 3-hydroxy-3-methylglutaryl-coenzyme A
SCOT succinyl-CoA-3-oxoacid-CoA transferase
BDH 3-hydroxybutyrate dehydrogenase
ICAM-1 intercellular cell adhesion molecule-1
VCAM-1 vascular cell adhesion protein-1
IL interleukin
MCP-1 monocyte chemoattractant protein-1
NOS NO synthase
TNF tumor necrosis factor
TGL triglyceride
TLR9 toll-like receptor 9
SIRT sirtuin
ROS reactive oxygen species
NAFLD non-alcoholic fatty liver disease
SREBP-1 sterol regulatory element-binding protein-1
PEPCK-1 phosphoenolpyruvate carboxykinase-1
FAS fatty acid synthase
ACC1 acetyl-CoA-carboxylase-1
SCD1 sterol-CoA desaturase-1
mTOR mammalian target of rapamycin
CKD chronic kidney disease
eGFR estimated glomerular filtration rate
HPTC human renal proximal tubular epithelial cell
EPO erythropoietin
HIF hypoxia inducible factor
AMPK AMP-activating protein kinase
NF-kB nuclear factor kappa B
PDH pyruvate dehydrogenase kinase-4
BA bronchial asthma
IDF International Diabetes Federation
ADA American Diabetes Association
EASD European Association for the Study of Diabetes
BP Blood pressure
HFD high-fat diet
PGC-1α peroxisome proliferator-activated receptor G coactivator 1-α
TFAM mitochondrial transcription factor A
Drp1 dynamin-related protein 1
Mfn mitofusin
OPA1 optic atrophy 1
CANVAS Canagliflozin Cardiovascular Assessment Study
FG Fournier’s gangrene