Figure 7.

Differential gene expression and related pathways in the V1 region after unilateral OHT.

(A) PCA analysis of the three groups (n = 3/group). (B) Number of total differentially expressed genes (DEGs) and up/down-regulated DEGs among the three groups. (C) Volcano plot of DEGs between the OHT-ipsi and OHT-contra sides. (D) Volcano plot of DEGs between the NC group and the OHT-contra side. (E) Volcano plot of DEGs between the NC group and the OHT-ipsi side. (F) Heatmap of characteristic DEGs between the NC group and OHT-contra side. (G) KEGG enrichment analysis of DEGs between the NC group and OHT-ipsi side. (H) KEGG enrichment analysis of DEGs between the NC group and OHT-contra side. (I) KEGG enrichment analysis of DEGs between the OHT-ipsi and OHT-contra sides. Contra: Contralateral; DEG: differentially expressed genes; Ipsi: ipsilateral; KEGG: Kyoto encyclopedia of genes and genomes; NC: no-treatment control; OHT: ocular hypertension.