Table 3.
Pharmacokinetic variables of insulin HumalogⓇ.
| Variable | HumalogⓇ control* (n = 4)† | HumalogⓇ/glucagon‡ (n = 4) | P value |
|---|---|---|---|
| Tmax (min) | 36 (30 to 40) | 31 (20 to 50) | 0.613 |
| Cmax (mU/L) | 37 (20 to 59) | 38 (20 to 56) | 0.839 |
| AUC0–15 (mU×min/L) | 64 (−4.8 to 134) | 306(−86 to 697) | 0.102 |
| AUC0–30 (mU×min/L) | 398 (113 to 684]) | 770 (35 to 1503) | 0.184 |
| AUC0–60 (mU×min/L) | 1493 (624 to 2363) | 1563 (719 to 2408) | 0.860 |
Tmax and Cmax were obtained directly from real time data. AUC was calculated as net area. Values in parentheses for Tmax are minimum to maximum values; Cmax values are delta mean (95% CI); values in parentheses for AUC are 95% CI.
⁎
Each pig received a 60-second subcutaneous infusion of 10 U of insulin.
†
Data have been published earlier.7
‡
Insulin (10 U) was premixed with glucagon (55 ng).