Table 1.
Sociodemographic, general health, and clinical characteristics of the overall NHWS population and the physician-diagnosed CSU cohort.
| Sociodemographic characteristics | Overall NHWS population (N = 74,994) | CSU (n = 635) |
|---|---|---|
| Age (years), mean (SD) | ||
| At data collection | 47.6 (17.3) | 39.6 (12.6) |
| At diagnosis | NA | 37.0 (17.1) |
| Gender, n (%) | ||
| Female | 42,664 (56.9) | 328 (51.7) |
| Race/ethnicity, n (%) | ||
| Asian | 5438 (7.3) | 34 (5.4) |
| Black/African American | 8326 (11.1) | 102 (16.1) |
| White, Hispanic | 8401 (11.2) | 112 (17.6) |
| White, non-Hispanic | 49,694 (66.3) | 371 (58.4) |
| Other | 3135 (4.2) | 16 (2.5) |
| Regional census, n (%) | ||
| North-East | 14,470 (19.3) | 135 (21.3) |
| Midwest | 15,644 (20.9) | 143 (22.5) |
| South | 27,810 (37.1) | 212 (33.4) |
| West | 17,070 (22.8) | 145 (22.8) |
| Education, n (%) | ||
| Less than a university degree | 37,051 (49.4) | 242 (38.1) |
| University degree | 37,793 (50.4) | 392 (61.7) |
| Declined to answer | 150 (0.2) | 1 (0.2) |
| Employment status, n (%) | ||
| Employed | 44,580 (59.4) | 504 (79.4) |
| Retired | 15,480 (20.6) | 48 (7.6) |
| Not employed | 8211 (10.9) | 34 (5.4) |
| Homemaker | 4215 (5.6) | 31 (4.9) |
| Disability (long-term/short-term) | 2508 (3.3) | 18 (2.8) |
| Annual household income, n (%) | ||
| Low: <$25,000 | 11,410 (15.2) | 58 (9.1) |
| Medium: $25,000 to $100,000 | 40,735 (54.3) | 273 (43.0) |
| High: $100,000+ | 19,251 (25.7) | 292 (46.0) |
| Declined to answer | 3598 (4.8) | 12 (1.9) |
| All-cause out-of-pocket costs in an average month, n (%) | ||
| $0 to $100 | 60,181 (80.2) | 407 (64.1) |
| $101 to $500 | 4961 (6.6) | 156 (24.6) |
| $501 to $1000 | 710 (0.9) | 37 (5.8) |
| $1001 or more | 411 (0.5) | 21 (3.3) |
| Do not know | 8731 (11.6) | 14 (2.2) |
| Health insurance status, n (%) | ||
| Has insurance | 66,484 (88.7) | 570 (89.8) |
| Commercial | 38,689 (51.6) | 434 (68.3) |
| Medicare | 16,499 (22.0) | 72 (11.3) |
| Medicaid | 5413 (7.2) | 45 (7.1) |
| Military | 2002 (2.7) | 11 (1.7) |
| Other | 3881 (5.2) | 8 (1.3) |
| Does not have insurance | 8510 (11.3) | 65 (10.2) |
| General health characteristics | ||
| CCI score, n (%) | ||
| 0 | 64,796 (86.4) | 327 (51.5) |
| 1 | 4662 (6.2) | 59 (9.3) |
| 2+ | 5536 (7.4) | 249 (39.2) |
| Body mass index, n (%) | ||
| Underweight (<18.5 kg/m2) | 2594 (3.5) | 103 (16.2) |
| Normal weight (18.5 to <25.0 kg/m2) | 24,749 (33.0) | 178 (28.0) |
| Overweight (25 to <30.0 kg/m2) | 21,970 (29.3) | 119 (18.7) |
| Obese (30.0 kg/m2 and above) | 21,926 (29.2) | 136 (21.4) |
| Declined to answer | 3755 (5.0) | 99 (15.6) |
| Clinical characteristics | ||
| Disease duration (years), mean (SD) | NA | 11.0 (12.6) |
| Angioedema in the past 3 months | ||
| Experienced angioedema, n (%) | NA | 312 (49.1) |
| Number of angioedema events, mean (SD) | NA | 3.9 (5.7) |
| Diagnosticiana, n (%) | ||
| Primary care physician/general practitioner | NA | 73 (36.3) |
| Nurse practitioner/physician assistant | NA | 10 (5.0) |
| Allergist | NA | 80 (39.8) |
| Dermatologist | NA | 33 (16.4) |
| Other | NA | 5 (2.5) |
| UCT, n (%) | ||
| Poorly controlled (UCT ≤11) | NA | 489 (77.0) |
| Well controlled (UCT ≥12) | NA | 146 (23.0) |
| Treatment patterns, n (%) | ||
| Treatment at time of surveyb | NA | 338 (53.2) |
| Prescription medication | NA | 61 (18.0) |
| OTC medication | NA | 312 (92.3) |
| Prescription and OTC medication | NA | 35 (10.4) |
| Prescribed medication classes | ||
| H1-antihistamines | NA | 43 (12.7) |
| Oral corticosteroids | NA | 14 (4.1) |
| Cyclosporine | NA | 6 (1.8) |
| Biologics | NA | 5 (1.5) |
| Other immunosuppressants | NA | 5 (1.5) |
| Doxepin | NA | 2 (0.6) |
| Other medications | NA | 20 (5.9) |
CCI, Charlson Comorbidity Index; CSU, chronic spontaneous urticaria; NA, not available; NHWS, National Health and Wellness Survey; OTC, over-the-counter; SD, standard deviation; UCT, urticaria control test.
a
The proportions calculated for diagnosticians were calculated with the number of missing responses (n = 434) excluded from the denominator. Therefore, the base sample for the proportion is the sum of respondents who provided a valid response (n = 201).
b
Not mutually exclusive.