Table 2.
Trans-Epithelial Electrical Resistance (TEER) (Ω/cm2) of Calu-3 cells and aspirin distribution at 4 h after treatment by ASA-API, sample A3 and F6.
Sample | TEER before deposition (Ω/cm2) | TEER 4 h after deposition (Ω/cm2) | 4 h cumulative drug permeated (%) | Cell surface (%) | Intracellular (%) |
---|---|---|---|---|---|
ASA-API | 427 ± 15 | 407 ± 10 | 35.27 ± 4.31 | 38.95 ± 3.12 | 25.78 ± 0.45 |
A3 | 405 ± 12 | 403 ± 5 | 69.87 ± 4.60 | 11.50 ± 1.11 | 18.63 ± 0.55 |
F6 | 392 ± 7 | 379 ± 6 | 77.15 ± 2.79 | 10.73 ± 1.96 | 12.12 ± 0.84 |