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. 2025 Jul 26;26:253. doi: 10.1186/s12931-025-03327-1

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Protocols for generation of patient-derived LCOs. (A) A protocol for establishing NSCLC organoid from tumor tissues. Reproduced with permission from Ref [60]., Copyright 2020, American Association for Cancer Research. (B) A protocol for generating LADC organoids from clinical patient tissue samples. Reproduced with permission from Ref [61]., Copyright 2021, Elsevier. (C) A workflow for generating LCOs using mechanically processed patient tumor tissues. Reproduced with permission from Ref [62]., Copyright 2021, Springer Nature. (D) Procedure for establishing COPD organoids. Reproduced with permission from Ref [63]., Copyright 2021, EMBO Press