Figure 1.

Cytotoxicity of VEGF₁₂₁/rGel to KDR-expressing PAE-transfected cells. Cells transfected with either the FLT-1 or KDR receptor were treated with various doses of VEGF₁₂₁/rGel or rGel for 72 h. Cells expressing the FLT-1 receptor were equally insensitive to VEGF₁₂₁/rGel and rGel (IC50 ≃ 300 nM). In contrast, cells expressing KDR were about 200-fold more sensitive to the fusion construct (IC₅₀ of 0.5 nM) than they were to rGel.