Figure 4.

Specific localization of VEGF/rGel to tumor vasculature in PC3 tumors. Nude mice bearing human prostate PC-3 tumors were injected i.v. with VEGF₁₂₁/rGel or rGel (2.5 mg/kg). Thirty minutes after administration, tissues were removed and snap frozen. Sections were stained with immunofluorescent reagents to detect murine blood vessels (MECA-32, red) and with anti-rGel (green). Vessels stained with both reagents appear yellow. VEGF/rGel localized to tumor vessels, whereas rGel did not. Vessels in all normal organs other than the kidney (glomerulus) were unstained by VEGF/rGel.