Table 2.

Human brain ADAR substrates with blastp hits

Gene product	Accession nos., RNA/gene	Editing	Repeat*	Function
Similar to CDK8	AY028424/Z84480	Intron	AluSx(+)†, AluJo(−)†	Unknown
NrCAM	AJ001057/AF172277	Intron	None	Cell adhesion, axon guidance (40)
PDE8A	AF056490/AC012064	Intron	None	cAMP hydrolysis (41)
Similar to ubiquitin hydrolase	AK001647/AC019221	Intron	LINE1	Unknown
HsC7-I	D26599‡/AL357035	3′ UTR	AluSc(+), AluJb(−)	Proteasome subunit (42)
NADH:ubiquinone oxidoreductase subunit B14.5B	BC007323/AC023532	3′ UTR	AluJb(+), AluSc(−)	Mitochondrial electron transport (43)
Tankyrase	AF082557/AC055869	3′ UTR	MER53	ADP-ribosylation of TRF (44)
PP2C-β	AF294792/hCG15783§	Intron	AluY(+)¶	Protein phosphatase (45)
PAR-SN	U55937/AC009696	Noncoding	AluJo(−), AluSx(+), AluSx(+)	snoRNA host (HBII-13) (30, 31)

^*(+) indicates that Alu is in sense orientation, (−) indicates antisense orientation. 

^† Only AluSx was sequenced, but RNase T1 cleavage site was in AluJo. 

^‡ mRNA sequence does not extend to edited region; a composite cDNA was constructed from expressed sequence tags to connect edited region to upstream ORF. 

^§ Accession no. for gene is from the Celera database. 

^¶ There are three antisense Alus within 1 kb of this Alu but RNA was not sequenced to determine if other Alus are edited.