The electrostatic surface potential of Aq1575. (Left) A molecular surface is created by the program GRASP (red, negative; blue, positive; white, uncharged) (40). The residues, 5–17 and 243–247, covering a cleft were deleted to show a clear view of the inside of the protein in both Left and Right. The putative active site (PAS1) is indicated. (Right) The figure was drawn after 180° rotation of Left versus y axis. The putative active sites (PAS1 and PAS2) are indicated.