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. 2025 Jul 14;18:1619583. doi: 10.3389/fnmol.2025.1619583

Figure 9.

Bar graphs (A and B) and scatter plots (C and D) depict research findings on control, MIA, MIA+OTX015, and OTX015 groups. A: Discrimination index, with notable p-value. B: Exploration time of familiar and novel objects, highlighting significant differences. C and D: Scatter plots show correlations between ID(NOR) and Aβ1–40, Aβ1–42 with regression lines and statistical details.

The effect of MIA and OTX-015 on memory function in 12-month-old male mice. The memory function of animals was analyzed in a novel object recognition (NOR) test. (A) The index of discrimination (ID) was calculated based on time spent exploring the novel object versus the familiar object, as described in the Methods section. (B) Relative exploration time of familiar vs. novel object in the NOR test. (C) The analysis of the correlation of the data from the NOR test with the levels of Aβ1-40 and Aβ1-42 (D) in corresponding animals was performed using Pearson’s correlation test. Presented results are means ± SEM from N = 10–11 animals in each group. n.s. – not significant, ***p < 0.001. Each data point (○) represents an individual animal. Statistical analyses were conducted using one-way ANOVA followed by the Bonferroni post hoc test, selected based on data distribution.