Table 2.

The effect of MIA and OTX-015 on the expression of inflammation-related genes in the hippocampus of 12-month-old male mice.

	Control	MIA	MIA+OTX015	OTX015
	[RQ]	[RQ]	[RQ]	[RQ]
Il1b	1.00 ± 0.16 (7)	0.83 ± 0.03 (6)	0.89 ± 0.07 (7)	0.79 ± 0.09 (8)
Il6	1.00 ± 0.19 (7)	1.53 ± 0.12 (8) &	1.71 ± 0.23 (7)	1.35 ± 0.22 (8)
Tnf	1.00 ± 0.27 (7)	1.13 ± 0.13 (8)	0.79 ± 0.15 (6)	0.78 ± 0.16 (8)
Nos2	1.00 ± 0.08 (6)	1.50 ± 0.17 (8) &	1.39 ± 0.28 (7)	0.92 ± 0.18 (8)
Arg1	1.00 ± 0.08 (6)	0.98 ± 0.12 (8)	0.88 ± 0.07 (6)	0.89 ± 0.16 (8)

PIC (20 mg/kg b.w.) was injected intraperitoneally at gestation day 17 to female mice. An inhibitor of BET proteins, OTX-015 (100 mg/kg b.w. daily), was administered orally to 12-month-old offspring males for 14 days (weeks 50–51), then animals were decapitated, and the brain tissue was collected. The level of mRNA was measured by using qPCR and calculated by the ΔΔCt method. The presented values are mean ± SEM (N). & p < 0.05, compared with the control group using the Student t-test. RQ, relative quantification.