Skip to main content
. 2025 Jul 26;39(14):e70881. doi: 10.1096/fj.202501793R

FIGURE 2.

FIGURE 2

Trem2 haploinsufficiency enhanced CNV and vascular leakage. (A) Representative images of CNV lesions in choroidal flat mounts from Trem2 wild‐type (Trem2 +/+ ) and Trem2 heterozygous (Trem2 +/− ) mice at day 7 post‐laser, stained with Lectin (red). Scale bar: 500 μm. (B) Quantification of CNV lesion area revealed significantly larger lesions in Trem2 +/− mice (n = 30 lesions) compared to Trem2 +/+ controls (n = 24 lesions). Data are presented as mean ± SEM. ***p < 0.001. (C) Immunostaining for IBA1 and quantification showed myeloid cell population in CNV lesions in Trem2 +/− mice (n = 12). Scale bar: 500 μm. (D) Representative fundus fluorescein angiography (FFA) demonstrated greater vascular leakage in Trem2 +/− mice relative to wild‐type controls (n = 6 eyes per group).